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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract: hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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Experimental Studies on Recombinant Hepatitis B Immunogenic Complex Therapeutic Vaccine (YIC)

Wenyu mei,He Lifang,Qu Di,Ma Zhangmei,Yao Xin

Strategic Study of CAE 1999, Volume 1, Issue 1,   Pages 38-42

Abstract: The Fc fragment of the anti-HBs in the complex could attach to the Fc receptors on the antigen presentingAfter being ingested, the antigen complexed to antibody could be more effectively processed and presentedEnhanced immune response in host has also been shown by comparing anti-HBs titer in mice immunized with antigen-antibodythe normal responsive counterpart mouse strain (BIO), immunization with HBsAg induced low titer of antibody

Keywords： hepatitis B     therapeutic vaccine     antigen-antibody complex     immune responses    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract:

CD176 (Thomsen-Friedenreich antigen) is a tumor-associated carbohydrate epitope (glycotope) functionallyWe applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage displayA positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 298-313 doi: 10.1007/s11684-018-0636-x

Abstract: While the association between antibody mediated rejection and allograft damage has been well establishedThe role of the antibody mediated immune response is discussed as well as the importance of pre-transplantFinally, potential mechanisms, which may act individually or in combination, of antibody mediated damage

Keywords： human leukocyte antigen class I and II     lung transplantation     mismatch     obliterans bronchiolitis     alloantibody     antibody mediated rejection    

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Modified Therapeutic Antibodies: Improving Efficacy Review

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Engineering 2021, Volume 7, Issue 11,   Pages 1529-1540 doi: 10.1016/j.eng.2020.06.030

Abstract: of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody–drug conjugates (ADCs); ⑤ single chain of variable region fragment (scFv) for chimeric antigen

Keywords： Therapeutic antibody     Modification     Efficacy     Antigen     Antibody–drug conjugate     Bispecific antibody    

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Optimal Antibody Purification Strategies Using Data-Driven Models Article

Songsong Liu, Lazaros G. Papageorgiou

Engineering 2019, Volume 5, Issue 6,   Pages 1077-1092 doi: 10.1016/j.eng.2019.10.011

Abstract:

This work addresses the multiscale optimization of the purification processes of antibody fragmentsnonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibody

Keywords： Antibody purification     Multiscale optimization     Antigen-binding fragment     Mixed-integer programming    

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Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(II) complexes and

Jihong LU, Danfeng ZHANG, Qian CHEN, Buwei YU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 19-25 doi: 10.1007/s11705-010-0546-1

Abstract: Two types of salicylaldiminato-based nickel complexes, mono-ligated Ni(II) complexes ([O-C H - - C(H)- -C(H)=N-Ar]Ni(PPh )(Ph) ( ), [O-(3- -Bu)C H - -C(H)=N-Ar]Ni(PPh )(Ph) ( )) and bis-ligated Ni(II) complexesIn the presence of methylaluminoxane (MAO) as cocatalyst, all the nickel complexes exhibited high activitiesThe complexes with less bulky substituents on salicylaldiminato framework possessed higher activities, while with the same salicylaldiminato, the mono-ligated nickel complexes showed higher catalytic activity

Keywords： late transition metal catalyst     methyl methacrylate     polymerization     salicylaldiminato nickel complexes    

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Exposure-response of Cr(III)-organic complexes to Saccharomyces cerevisiae

Nivedita CHATTERJEE, Zejiao LUO,

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 2,   Pages 196-202 doi: 10.1007/s11783-010-0008-5

Abstract: Hexavalent chromium [Cr(VI)] bioreduction produces soluble Cr(III)-organic complexes.The Cr(III)-organic complexes are relatively stable once they are formed, and no data about their toxicityTherefore, this study aims to investigate the bioavailability and toxicity of the soluble Cr(III)-organic complexesmodel organism and Cr(III)-citrate was selected as the representative compound of the Cr(III)-organic complexes

Keywords： Cr(III)-organic complexes     Saccharomyces cerevisiae     toxicity     EC50     bioavailability    

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Synthesis of p -substituted tetraphenylporphyrins and corresponding ferric complexes with mixed-solvents

Zhicheng SUN, Yuanbin SHE, Rugang ZHONG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 457-461 doi: 10.1007/s11705-009-0169-6

Abstract: pyrrole in mixed solvents (propionic acid, acetic acid and nitrobenzene), and corresponding ferric complexeswere obtained in 30%–50% yields, metalation yields were up to 90% and total yields of ferric complexesStructures of the above porphyrin complexes were characterized by ultraviolet-visible (UV-Vis), infrared

Keywords： -substituted tetraphenylporphyrin     condensation     -substituted benzaldehyde     dimethylformamide     metalation    

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Preparation, identification, and clinical application of anti-HBs monoclonal antibody that binds both

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 277-283 doi: 10.1007/s11684-009-0047-0

Abstract: enzyme-linked immunosorbent assay (ELISA), a hybridoma cell line strain secreting anti-HBs monoclonal antibodyAntibody titers in the culture supernatant and ascites were 2.048×10 and 4.096×10, respectivelyBy applying the anti-HBs G6 mAb and horseradish peroxidase (HRP)-labeled goat anti-HBs antibody, we developed

Keywords： hepatitis B virus     gene variation     hepatitis B surface antigen     immune escape     enzyme-linked immunosorbent    

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Synthesis of iron(II) complexes with asymmetric N

Wolfgang Bauer, Tanja Ossiander, Birgit Weber

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 400-408 doi: 10.1007/s11705-018-1753-4

Abstract: p>The synthesis of new Schiff base-like ligands with asymmetric substituents pattern and their iron complexesTwo of the ligands and one of the iron(II) complexes were characterized by single crystal X-ray structureOne of the the iron(II) complexes shows spin crossover behavior while the others remain in the high spinThe influence of the reduced symmetry of the ligand on the properties of the complexes is discussed.

Keywords： iron     Schiff base-like ligands     magnetism     spin crossover     X-ray structures    

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Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Abstract Chimeric antigen receptor T cell (CAR T) therapies have achieved unprecedented efficacy in B-cellAlthough the identification of an ideal target antigen for AML is challenging, CAR T therapy remains

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract: transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially+positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen

Keywords： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently underdose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependentdemonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibodyFurthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: Antibody therapies encompassing convalescent plasma, hyperimmunoglobulin, and neutralizing monoclonalIn addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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Title Author Date Type Operation

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Experimental Studies on Recombinant Hepatitis B Immunogenic Complex Therapeutic Vaccine (YIC)

Wenyu mei,He Lifang,Qu Di,Ma Zhangmei,Yao Xin

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

Journal Article

Modified Therapeutic Antibodies: Improving Efficacy

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Journal Article

Optimal Antibody Purification Strategies Using Data-Driven Models

Songsong Liu, Lazaros G. Papageorgiou

Journal Article

Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(II) complexes and

Jihong LU, Danfeng ZHANG, Qian CHEN, Buwei YU

Journal Article

Exposure-response of Cr(III)-organic complexes to Saccharomyces cerevisiae

Nivedita CHATTERJEE, Zejiao LUO,

Journal Article

Synthesis of p -substituted tetraphenylporphyrins and corresponding ferric complexes with mixed-solvents

Zhicheng SUN, Yuanbin SHE, Rugang ZHONG,

Journal Article

Preparation, identification, and clinical application of anti-HBs monoclonal antibody that binds both

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Journal Article

Synthesis of iron(II) complexes with asymmetric N

Wolfgang Bauer, Tanja Ossiander, Birgit Weber

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article